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[DOI] [PubMed] [Google Scholar] 199.Piletz J.E., Aricioglu F., Cheng J.T., Fairbanks C.A., Gilad V.H., Haenisch B., Halaris A., Hong S., Lee J.E., Li J., et al

Gut 62 , 1521 (2013)

5.1 Metabolic auxotrophy as an attenuation strategy Metabolic auxotrophy is a classic attenuation approach in which one or more critical genes in vital metabolite biosynthetic pathways are deleted, thereby causing the bacterial cell to rely on an exogenous supply of the targeted metabolite

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