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Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain

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Increased expression of cpt1 and ehhadh was observed in the liver of Danio rerio that received Mildronate [16]

In order to measure ambulatory locomotor activity in the different treatment groups, mice ( n = 8 per group) were single housed in metabolic cages (Phenomaster, TSE systems) at approximately 21 C, with a 12-h daily light cycle for 48 h in weeks 1921

Serum and liver tissue samples were collected from the mouse at 0, 1, 3 and 7 d (3 mouse at each time point) after anesthesia