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Taken together, these data provide further understanding into the regulation of CBS and in particular into the genetic relationship between DYRK1A and CBS through the Akt/GSK3 and NF-B pathways, which should help develop more effective therapies to reduce cognitive deficits in people with DS

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[DOI] [Google Scholar] 59.Van Maldegem A.M., Bove J.V.M.G., Peterse E.F.P., Hogendoorn P.C.W., Gelderblom H

The chemiluminescent substrate (ThermoFischer Scientific Inc.) was applied to the blot according to the manufacturers recommendation