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Recently endosomal processing has been demonstrated to play a pivotal role in the progression of HCC (Sorkin and von Zastrow, 2009
In contrast, TNB-738, a novel inhibitory antibody targeting human CD38 ecto-enzyme, is non-cytotoxic and could be used for indications where depletion of CD38-positive cells is not desired 25
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The latter depends on the bidirectional communication between tubular epithelial cells and fibroblasts 133
