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Excess Mn can disrupt glutamate homeostasis by impairing synaptic reuptake, leading to glutamate excitotoxicity, neuronal overexcitation, and damage (Johnson et al., 2018

At the lower doses used by most steroid users, discontinuation due to side effects is even less common

In case of an emergency unblinding, the reason and time of unblinding will be documented in the study files

Sprague et al, 2008)

This is why heavy drinkers are at significantly higher risk even from smaller doses of acetaminophen
