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Glutathione is a required substrate for a family of enzymes called glutathione S-transferases, which conjugate glutathione to reactive compounds including drug metabolites and environmental toxins making them water-soluble for excretion

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This well-known antioxidant effect has led during the past decade to an increased diffusion of GSH-based self-prescribed implementation by patients, aiming to prevent cell injury possibly leading to cancer onset or to reduce anticancer treatments toxicities when cancer has already been diagnosed

[Oxidative stress after preterm birth: origins, biomarkers, and possible therapeutic approaches]

Likewise, hyperhomocysteinemia depletes neuronal ATP and enhances the sensitivity of dopaminergic neurons to the toxic effect of rotenone in rats (Duan et al