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Analysis of these potential ligands in vitro suggests that FeGSH complexes are likely the only species that forms at significant levels in cells, largely because GSH is present at relatively high (210 mM) levels in the cytosol and exhibits moderate affinity ( K d 8 M) for Fe(II) (Sipos et al., 2002
doi: 10.1002/iub.337 48 GirardC
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Interferonopathies Mendelian disorders associated with upregulation of interferon
However, iron overload in patients with hemochromatosis results in excessive PS externalization and calpain activation in RBCs [83]
