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In addition, the TGF-B1 level was significantly increased in bleomycin-treated rats compared with their levels in TQ-PLGA-PVA-NP-treated rats (Saghir et al., 2019)

Table 2 Comparison of Hemi-MASI SCORE and its reduction % between both sides of the face in two groups By grading and comparing reduction percentages of Hemi-MASI score

1 : a001651

If we accept the context dependency of microbial-mediated IR is inevitable, we need to focus on developing environmentally stable commercial formulations and compositions of secondary metabolites of beneficial microbes that are known to trigger the resistance in laboratory conditions, as they may induce resistance consistently under field conditions as well