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Patients with conditions showing strong preclinical evidence and limited alternative treatment options may represent reasonable candidates following thorough informed consent discussions

Importantly, it remains unclear how the TMEM106B haplotype modifies a disease risk across various neurodegenerative diseases as well as brain aging (BOX 1)

123 While one study observed a significant improvement of upper extremity function during RAS, 124 music therapy was found to reduce agitation, and improve orientation levels compared to no music

Clin Cancer Res 2009;15(7):25592566

Potassium ion channel openers, Maxipost and Retigabine, protect against peripheral salicylate ototoxicity in rats