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Infection-induced hypoxia and inflammatory stimuli upregulate HIF-1, which then enhances immune cell metabolism and inflammatory responses, while disrupting osteoblast/osteoclast balance to aggravate bone destruction
[31] [32] [33] Similarly, in humans, renal proximal tubular cells contain high concentrations of alpha GST, while distal tubular cells contain pi GST
They aid in nutrient absorption and the development of the hosts immune system, playing a vital role in safeguarding the host against infections
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