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Another systematic review of six prospective cohort studies with a total of 1,84,010 participants with 18,076 incident CVD events has found no positive relationship between dietary choline or betaine intake and CVD incidence (Meyer and Shea, 2017)
Biochemical considerations

In vivo and ex vivo animal studies have indicated that 3 PUFAs reduce the production of TNF-, IL-1, IL-2, and IL-6 [187189]

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