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For example, in tumors with active growth factor receptor signaling (e.g., HER2 amplification), tamoxifen may lose its estrogen antagonist activity and acquire more agonist-like activity, resulting in tumor growth stimulation [34]

Bido S, Muggeo S, Massimino L, Marzi MJ, Giannelli SG, Melacini E, et al

Polyphenols (flavonoids, phenolic acids) and carotenoids contribute to redox/inflammatory control, with plausible higher functional relevance luteally (increased ROS), but total flavonoid intake shows limited associations with E2, P4, or prolactin in premenopausal women, though low carotenoid status links to irregularity (OR 1.21.5) [167]

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Diabetes Care 36 , 31313138 (2013)