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Hoff et al., 2024) (Fig
Research Highlights No peer-reviewed studies published as of June 2025
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For researchers, HPLC provides a quantitative estimate of purity
Kratom extracts induced pregnane X receptormediated upregulation of CYP3A4 and CYP1A2 expression, while MG and related alkaloids competitively inhibited CYP2D6 and CYP3A4/5 under acute incubation conditions [30, 31]
