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In addition, fibroblasts from individuals affected by HGPS, or from mice lacking ZmPSTe24, demonstrate a marked delay in the recruitment of p53 binding protein 1 (53BP1) to sites of DNA repair upon exposure to DSB-inducing irradiation (Liu et al., 2005)
Such cases are designated as cancer of unknown primary, which constitutes an estimated 31,000 new diagnoses annually in the United States (9)
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