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Fulvestrant is the first SERD approved for clinical use to treat advanced and metastatic breast cancer

Preclinical and in vitro studies document its utility in investigating collagen and glycosaminoglycan synthesis, VEGF-mediated angiogenesis pathways, superoxide dismutase activity, fibroblast migration and proliferation assays, and decorin gene expression research

[5] Pyridoxine (vitamin B) is converted to pyridoxal-5-phosphate, a coenzyme for over 100 enzymes in amino acid metabolism