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Peptides Peptides can penetrate through the BBB with the help of special transporters [195], receptors [196], or using the lipophilicity of substances [197]

For example, BACH1 attracts Nanog homeobox (NANOG) and mixedlineage leukemia/SET domaincontaining (MLL/SET1) complexes to chromatin, preserving H3K4me3 and enhancerpromoter activity on genes related to pluripotency in mouse embryonic stem cells (mESCs), [ 18 ] and recruits coactivatorassociated arginine methyltransferase 1 (CARM1) to activate the genes transcription during in vitro VSMC differentiation from hESCs

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[DOI] [PubMed] [Google Scholar] Chen ML, Tsai TC, Wang LK, Lin YY, Tsai YM, Lee MC, Tsai FM (2012) Risperidone modulates the cytokine and chemokine release of dendritic cells and induces TNF--directed cell apoptosis in neutrophils

[DOI] [PubMed] [Google Scholar] Rahman SA, Castanon-Cervantes O, Scheer FA, Shea SA, Czeisler CA, Davidson AJ, Lockley SW