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Therapeutic implications: modulating nodes, not just scavenging Therapy should target network nodes and compartments, not just mop up oxidants: indiscriminate antioxidant loading can blunt adaptive signalling and leave the upstream drivers untouched, whereas node-specific, compartment-aware strategies act where the chemistry originates and where signals are decoded
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The extensive mixture of different oxidation species made this system difficult to monitor (see Fig
This mechanism probably contributed to the PC progress in-vitro
