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Description
Grschow S
During hypoxia, when O 2 becomes limiting, activity of HO2 and CO production drops, relieving the inhibition on CBS, which can then produce H 2 S to mediate arteriolar vasodilation (Morikawa et al ., 2012)
These sequential cleavages produce effector molecules such as C3a, C4a, and C5a, collectively known as anaphylatoxins, that modulate inflammation, chemotaxis, vascular permeability, and cellular oxidative responses
C.Al-GhalithG
& Peschel, A
