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Description
The binding of H1 peptides to the tetrameric c-Myc-92 is the mechanism of inhibition [43]
These are not comparable treatments
The failure of NE inhibitors alone (116), and the data for brensocatib in the Phase 2 WILLOW trial (115, 202), suggests that combined inhibition of NSPs, as well as inhibition prior to extracellular release by the neutrophils, may be required for observation of efficacy in bronchiectasis
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Oral administration: 0.5-1 mg daily to compensate for lower bioavailability compared to injection
