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In humans, cyanocobalamin must undergo intracellular enzymatic conversion to the active coenzyme formsmethylcobalamin and adenosylcobalaminwhich, depending on the pH environment, can interconvert with hydroxocobalamin (Gherasim et al., 2013), the most common B12 form in both food and human plasma (Obeid et al., 2015)

10.1038/s41586-025-08589-9 88 SongM.-S.BustosA

All mice were acclimated to laboratory conditions for 1 week before starting the experiments, followed by 1 week of acclimatization to normal powder chow before the starting of experiments at 8 weeks of age

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