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Recently, a native-like trimeric S protein was reported for a COVID-19 subunit vaccine candidate being developed in China, in which the S protein is fused to a trimer-tag, the C-terminal region of human type I collagen, to form a disulfide-bonded homotrimer 82

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(c) in warfarin rats (warfarin given intragastrically (1.5 mg/kg) once daily for 3 consecutive days, with the last challenge was at 3 hours before the bleeding procedure)

Risks Immune responses differ by sequence of the peptides, carrier, and patient background
