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In addition, according to bioinformatics data, the ferroptosis-related factor APOE4 may be closely related to m6A methylation regulators in the brain tissue of AD patients (METTL3, METTL16, YTHDC2, and LRPPRC) (Du et al., 2021)

We constructed EWSRGGF by replacing RGG3 with RGGF in EWS (Fig

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Research suggests that many of these leads could be non-optimizable due to the presence of pan assay interference compounds (PAINS) or other promiscuous groups (Pouliot and Jeanmart, 2016)

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