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Regarding the inflammatory component in neuronal disorders, ALA and DHLA inhibit inflammasomes in neural tissues by decreasing pro-inflammatory mediators, such as interleukin-2 (IL-2), IFN-, and TNF-, increasing anti-inflammatory cytokines such as interleukin-10 (IL-10), and regulating the transcription of nuclear factors Nrf2 and NF-B in physiological processes

29 Some case reports have linked sarcoidosis with an increased risk of developing Budd-Chiari 30 syndrome, hepatopulmonary syndrome, 28 hepatocellular carcinoma, 31,32 and biliary sarcoid mimicking cholangiocarcinoma

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Med Sci Monit 7:801819 Hancock JT, Neill SJ (2019) Nitric oxide: its generation and interactions with other reactive signaling compounds in plants