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Biomonitoring data were integrated using reverse dosimetry to estimate external exposure levels, and margins of safety were then calculated by comparing these estimates with established reference doses

Thus, in animals Tyr must be acquired through the diet or produced from L-phenylalanine (Phe) by Phe-hydroxylase (Fitzpatrick, Tyr is synthesized from prephenate, downstream of the shikimate pathway, by two alternative routes

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