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Management of endocrine disease: rituximab therapy for Graves orbitopathy - lessons from randomized control trials

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Expression of Socs3 , but not of Socs1 or Socs2 , is rapidly induced in the hypothalamus of ob/ob mice in response to peripheral administration of leptin, and overexpression of Socs3 blocks leptin-induced signal transduction in cultured mammalian cell lines 68

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