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Studies have shown that plasma TMAO may affect the course of various cardiovascular disorders and increase the risk of MI, despite the lack of direct relationships [65, 79]

doi: 10.1016/s0161-6420(93)31420-x

however, it cannot be ruled out that higher hydroxyproline levels in the muscle of pen-finished animals is also the result of their diet, which may have been higher in hydroxyproline [56]

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