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Thus, the impairment of astrocyte glycolysis might contribute to synaptic dysfunction in AD

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In human observational studies, both the AEDG peptide and its parent extract epithalamin were associated with significant telomere length increases in blood cells of subjects aged 6080, with a separate study documenting an 1119% increase in telomere length in subjects aged 6080 receiving the pineal peptide bioregulator (5)

In one study, researchers found that bilirubin significantly inhibited autophagy in the human colon adenocarcinoma cell lines of LS180 and SW480 cells by suppressing Beclin-1 and Microtubule-Associated Protein 1 Light Chain 3B (LC-3B) in the cells, and increased apoptosis by the upregulation of p53 in LS180 cells and downregulation of the Bcl-2 gene which inhibits apoptosis in SW480 cells ( 5.1.2.2 NF-B Nuclear factor-B (NF-B) is a nuclear factor family consisting of multiple transcription factors involved in regulating inflammatory response, cell proliferation, tumor development, and invasion

This process is mainly reliant on Sodium-dependent Vitamin C Transporters (SVCTs) and Sodium-independent facilitative glucose transporters (GLUTs) [6, 36, 37]