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However, limitations exist in the form of in vivo instability, the reliance on carriers that are biocompatible and robust and limited sites of application (local and direct) (Park et al
doi: 10.1016/j.alit.2021.07.003 18

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Subcutaneous injection bypasses the gastrointestinal tract entirely
Osteoclasts are recognized as the exclusive cells responsible for bone resorption (34)