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Lung Radiation-induced lung injury (RILI) is a prevalent and potentially fatal off-target effect of thoracic radiotherapy, with limited effective interventions available [56, 69, 70]

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In vitro studies demonstrate that cancer-associated fibroblasts (CAFs) support hormone-sensitive prostate cancer (HSPC) proliferation via glutamine and -KG secretion, fueling energy and biosynthetic demands (194, 195)

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