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In the classic db/db mouse model of metabolic fatty liver, oral administration of betaine can inhibit the interaction between forkhead box protein O6 and peroxisome proliferator-activated receptor gamma (PPAR), inhibit the expression of primary lipogenic genes, such as fatty acid synthase (FAS) and acetyl-CoA carboxylase, and reduce hepatic lipid accumulation (77, 78)

Studies have examined their effects on wound healing in diabetic patients, collagen synthesis in human skin, hair follicle enlargement and gene expression in skin cells

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Control Release 213 , 128133 (2015)