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They're unrealistic expectations, poor preparation technique, or failure to address the underlying mechanical or behavioral factors perpetuating the injury

Trends Pharmacol

Olokizumab, a monoclonal antibody against interleukin-6, in combination with methotrexate in patients with rheumatoid arthritis inadequately controlled by tumour necrosis factor inhibitor therapy: efficacy and safety results of a randomised controlled phase III study

compared all factors in a 2-month trial and in a 1-year trial (1), and Varady et al

coli O55:B5 may decrease P-gp activity in brain ECs in a microglia-dependent way after 6 hours treatment (Matsumoto et al., 2012)
