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While L-arginine was popular for its quick effects, it suffered from poor bioavailability due to rapid conversion by the arginase enzyme

Meanwhile, we detected the HIF-1, a key protein in the mechanism of APAP-induced liver injury 35 and found that 5-HT could decrease the expression of HIF-1 by which 5-HT contributed to relieve of APAP-induced hepatotoxicity (Figure 8D and 8E)

Selective estrogen receptor modulators (SERMs) and selective estrogen receptor degraders (SERDs) in cancer treatment

1979 Jul 15;103(2):287290