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Spermidine can reduce the expression of TFR1 and ALOX15, and upregulate Nrf2 and SLC7A11 expression

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Chen et al., 2020

It is what the published clinical evidence shows about each peptides mechanism, half-life, FDA approval status, and demonstrated effects

The copper ion itself serves as a cofactor for lysyl oxidase, the enzyme responsible for collagen and elastin cross-linking, meaning GHK-Cu both stimulates production of new structural proteins and ensures they are properly stabilized