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Although ROS play essential roles in the maintenance of basal cellular activities such as chondrocyte proliferation and matrix remodeling in cartilage, excessive oxidative stress causes detrimental events such as cellular senescence 36,121 , dedifferentiation 122 , and apoptosis 123

Di Pierro D, Ciaccio C, Sbardella D, Tundo GR, Bernardini R, Curatolo P, et al

VLCFA may be the biological messengers that convey redox information between peroxisomes and mitochondria in X-ALD and then induce mitochondrial oxidative stress

In addition to oxalic acid in foods, hydroxyproline is an amino acid found in many protein-rich foods that can be metabolized into oxalates
