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Notably, PGE2 suppresses the activation and activity of T cells by enhancing PD-L1 expression and the polarization of TAMs through cAMP and mitochondrial signals, thereby forming a positive feedback cycle [62, 63]

Accompanied by direct glutathionylation of GAPDH in glycolysis, glucose metabolism was altered by vitamin C treatment

The incidence of dementia among DS patients is 10% in the age range 3550 yr and 55% in the age range 5060 yr and becomes 75% above the age of 60 yr, but AD neuropathology is present in virtually all adults with DS older than 40 yr (460)

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