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Additionally, PAHs, such as benzo[a]pyrene, are oxidized in the liver by CYP1A1 and CYP1B1 to form epoxides, which are subsequently hydrolyzed by epoxide hydrolase (EH) into highly reactive diol epoxides (e.g., BPDE), thereby driving the molecular mechanisms of bladder cancer (Thier et al., 2003

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