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Differences Between Short-Acting and Long-Acting Benzodiazepine Withdrawal Short-acting benzodiazepines, such as alprazolam and triazolam, have a rapid onset and relatively brief half-life, leading to more pronounced and frequent withdrawal symptoms

Symptoms include persistent redness, new breakouts, and skin sensitivity that worsens over time instead of improving

Animal experiments have also confirmed that hypoxia and cerebral microvascular lesions can act together to aggravate vascular endothelial damage and damage-related brain regions (54)

doi: 10.1016/j.jmoldx.2021.07.027 58 ChoBCChiuCHMassarelliEBuchschacherGLGotoKOverbeckTRet al

Vreones M, Mustapic M, Moaddel R, Pucha KA, Lovett J, Seals DR, et al