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Preclinical evidence is strong and coherent

161,163 It can cause adverse side effects such as dry mouth, lethargy, weight gain, and dizziness

May improve skin quality and markers of dermal density over time in observational and experimental contexts

Recently, Masahiro et al showed that chronic hyperglycemia resulted in enhanced apoptosis in human brain endothelial cells, which was attenuated by insulin (Masahiro et al., 2006)
