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Approximately 15-20 percent of patients with Graves disease have been reported to have spontaneous hypothyroidism, thought to be due to the extended immune response of having Graves disease

By the Bayesian framework, the estimated prevalence of PCD was 1:17,576 (95% confidence interval: 1:22,5511:14,001)

ISL2 is a putative tumor suppressor whose epigenetic silencing reprograms the metabolism of pancreatic cancer

DRAK2 has been shown to phosphorylate S6K1 (139), an important target of mTOR and of TCR signaling that impacts cellular metabolism (57, 140)

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