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Other research has shown people with liver disease who received high doses of glutathione via an IV had improvements in their liver function tests

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Marked redox changes in hepatocytes, by using oxidants or GSH depletion agents, cause necrosis, whereas modest redox changes sensitize hepatocytes to tumor necrosis factor (TNF)-induced apoptosis by inhibiting the expression of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB)-dependent survival genes [44]