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Optic nerve atrophy can worsen in patients whose methylcobalamin levels are already elevated

Functional morphology of the bloodbrain barrier in health and disease
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Because liposomal formulations have been shown to maintain elevated plasma levels for extended periods, splitting the dose (one in the morning and one in the evening) can help provide a continuous, 24-hour shield of antioxidant protection against ongoing systemic inflammation
, McGeer, P
