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Akt (protein kinase B) is over-activated in many types of cancers and promotes multiple cell survival mechanisms

A., Conran N

doi: 10.1074/jbc.R113.472936, 81

In addition, the activity and expression of SLC7A11 is strictly regulated by multiple mechanisms, such as transcription factor 4 (ATF4), nuclear factor erythroid 2related factor 2 (NRF2), ubiquitin BRCA1 (Breast cancer gene 1)-associated protein-1 (BAP1), the SWI/SNF complex, and rapamycin complex 1 (mTORC1) (51), through which the expression of SLC7A11 can be upregulated to enhance the antioxidant defense of cells and inhibit the occurrence of ferroptosis ( Figure 1B )

We also monitored weight gain or loss on the standard lab chow (control) and the ketogenic diet (Figure 1C), finding no significant differences across sex or group