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The colorectal cancer evidence is strongest: dietary fiber, resistant starch, and short-chain fatty acids, especially butyrate, produced via microbial fermentation of plant polysaccharides in the colon synergistically protect the colonic epithelium by reducing fecal transit time, diluting and adsorbing potential carcinogens, maintaining mucosal barrier integrity, activating tumor suppressor genes, and promoting apoptosis in pre-malignant colonocytes (50, 51)