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Preclinical studies have shown that co-targeting ferroptosis and pyroptosis (e.g., GPX4 inhibitor + GSDMD activator) can overcome compensatory resistance by engaging complementary cell death mechanisms, amplifying DAMP release, and enhancing T cell infiltration (60, 181)

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Cystatins, along with stefins and kininogens, belong to a superfamily of cysteine protease inhibitors found across metazoan and plant taxa

The glutathione concentration of unknown sample is measured by measuring the absorbance at 415 nm and comparing it with standard curve for GSSG, which is plotted new every time when glutathione quantification is done