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Anti-inflammatory diets reduce the risk of autoimmune diseases, but the penetration rate is less than 15% (Khavandegar et al., 2024

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BH: Formal analysis, Writing review & editing, Conceptualization, Writing original draft, Investigation

Bao et al (60) found downregulation of the ferroptosis regulator GPX4 in both Fpnfl/fl/NEXcre (NEX-Cre mice were mated with Fpn-floxed (Fpnfl/fl) mice to generate conditional Fpnfl/fl/NEXcre mice.) and APPswe/PS1dE9 (Carrying genetically modified mice with AD-related mutations: a chimeric mouse/human APP with the Swedish mutation and human PSEN1 lacking exon 9) mouse models compared with controls

The fact that Yap1 deficiency extends the egtA phenotype indicates that in wild-type, EGT limitation is partially compensated by other detoxification mechanisms that require activation by Yap1