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Conversely, ALD is driven by excessive ethanol metabolism, which directly consumes NAD + and markedly increases the NADH/NAD + ratio

Abstract Neuroactive steroids synthesized within the maternal-placental-fetal unit play a crucial role in fetal neurodevelopment by regulating cell proliferation, migration, and myelination, neurogenesis, gliogenesis, and synaptogenesis, ultimately shaping brain maturation