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The accumulation of genome sequence data in previous decades revealed several GST homologs organized in complex supergene families in a wide range of plants (Labrou et al., 2015)

It has been postulated that trastuzumab emtansine likely undergoes proteolytic cleavage at the lysine residue from the antibody portion to give lysine-linker-drug as a major active metabolite after lysosomal degradation 71

However, this combination is not approved by the FDA and has not been tested for safety and efficacy in clinical trials

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