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LCN2, a secreted glycoprotein, forms a complex with bacterial and human siderophores, thereby inhibiting bacterial growth and regulating iron homeostasis that maintains the integrity of the gastrointestinal mucosa (Xiao et al., 2017)

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On the other hand, Nrf2-deficient mice have been shown to be susceptible to cigarette smoke-induced emphysema [265], hyperoxic lung injury [266], and pulmonary fibrosis [267]

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