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The accumulation of AEGs and their binding to the receptor for glycosylation end-products (RAGE) promotes oxidative stress, which activates the NF-B signalling pathway, upregulates the expression of target genes and triggers inflammation (22)

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[1] [2] The vitamin's water-soluble nature means that excess amounts are typically excreted through urine rather than accumulating in the body to toxic levels

PlexusDx works with licensed 503A compounding pharmacies and recommends medical supervision during treatment to monitor tolerability and efficacy