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Additional approaches, including siRNA-mediated NOX4 silencing and selective NOX1/4 inhibition, are being explored as potential therapeutic interventions [115, 116]

This can be done by beginning with examining substances for which there are reports of their potential toxicity to the intestinal barrier and determining the degree of toxicity, monitoring the concentrations in the environment and various products of compounds toxic to the intestinal barrier, as well as limiting contact with substances that may cause intestinal leakage to doses that could be considered safe

This approach is in line with previous metabolomic studies that have adopted a similar rationale ( vs

2020;31:80921.e806

Extended B cell phenotype in patients with myalgic encephalomyelitis/chronic fatigue syndrome: a cross-sectional study